Buy CJC-1295
What is CJC-1295 and what is DAC?
If you want to buy CJC-1295 without DAC, it is useful to know what CJC-1295 is and what DAC is. Regular CJC-1295 contains DAC, a protective layer that makes this peptide active 8 times as long as other peptides. We choose to sell CJC-1295 without DAC so that it can be better combined with other peptides. For readability we will continue to call it CJC-1295, but please note that it concerns the variant without DAC.
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) that increases plasma levels of growth hormone and insulin-like growth factor 1 (IGF-1).
Growth hormone-releasing hormone (GHRH) has been modified several times to produce analogues that retain some of the hormone’s effects while eliminating others. One such modification, CJC-1295, consists of only the first 29 amino acids of GHRH. This analogue of GHRH, which is technically a maleimido derivative of hGRF(1-29), was created in an attempt to produce a more soluble GH secretagogue that is easier to produce in large quantities but still has the physiological effects of GHRH.
Effects of CJC-1295
As a derivative of GHRH, it should come as no surprise that CJC-1295 promotes GH release. Studies show that a single dose of CJC-1295 increases GH levels in mice by 2-10 times. Peak levels of GH are reached approximately 2 hours after administration and the effects last approximately six days. Unlike other GH secretagogues, CJC-1295 maintains normal physiological GH release. This means that the normal circadian peaks and valleys seen in GH release remain intact. Therefor, CJC-1295 is a physiological growth hormone releasing factor.
Maintaining the physiological release of GH, even while affecting the maximum concentration of the hormone in the bloodstream, is crucial to ensure enhanced effects without increased side effects. Notably, CJC-1295 has been shown to preserve the physiological effects of growth hormone on hyperplasia, hypertrophy, bone density, blood sugar, lipid metabolism, protein synthesis and myocardial function.
CJC-1295 and Growth Studies in mice lacking normal GHRH physiology have shown that CJC-1295 maintains normal GH release. This makes the peptide potentially useful as a therapy for abnormal growth in several mammalian species, including humans. Maintaining normal pulsatile GH release is crucial to ensure that proper release of downstream hormones, such as insulin-like growth factor-2 (IGF-1), occurs.
Research of CJC-1295
Research from the early 1990s suggests that CJC-1295 and other GRF analogues may be useful in promoting ovulation in infertile female patients. Scientists have long known that ovulation is dependent on IGF-1 and is likely also influenced by GH release and cycling. Research in animal models of superovulation helped to confirm theories by showing that both GH and IGF-1 levels rise significantly around the time of ovulation. Furthermore, these studies indicate that exogenous administration of GH secretagogues, such as CJC-1295, is sufficient to induce appropriate ovulation. There is some speculation that CJC-1295 and other analogs may even be useful in male infertility by helping to regulate sperm production. However, this last hypothesis remains to be tested.
CJC-1295 exhibits moderate side effects, low oral and excellent subcutaneous bioavailability in mice. The dosage per kg in mice does not scale to humans.
Conclusion
CJC-1295 is a growth hormone secretagogue designed to have a long plasma half-life and maintain the physiological patterns inherent to the GH axis. The molecule has proven to be a success on both fronts. CJC-1295 has had limited interest in research settings due to the advent of a number of similar molecules and due to the proprietary nature of the molecule’s structure. Now that CJC-1295 can be produced at will, there is likely renewed interest in its properties. Particularly as they apply to the increasingly frustrating problem of human infertility.
Hazard statement CJC-1295
Avoid contact with Bronchogen’s eyes as this may cause irritation. In case of contact with eyes, rinse with water for several minutes and remove contact lenses if necessary.
View the Material Safety Datasheet of CJC-1295
Is it legal to buy CJC-1295 without DAC?
Yes, anyone over the age of 18 can buy CJC-1295 because it is a research compound. Peptides are subject to various government rules and regulations. As a result, we are not permitted to present health claims or specify consumption methods. We supply CJC-1295 freeze-dried, with the choice between a spray bottle or a glass ampoule. This so that people can make their own choice about how they will research the CJC-1295. This ensures shelf life: from the moment you mix the CJC-1295 in the spray bottle or glass ampoule with sterile water, it is effective and has a shelf life for 3 weeks.
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